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Holy Shit Tech

A hard-to-treat colorectal tumor may lack a supply line, not soldiers: a Shenzhen, China team reports in Science that OX40 plus PD-1 rewired immunity in mice ↗

Lei Zhang’s group at Shenzhen Bay Laboratory reports in Science that PD-1–responsive colorectal tumors contain a spatial niche of helper T cells that arrive from lymph nodes. In mice, an OX40 agonist plus PD-1 blockade pushed that peripheral supply line and slowed tumor growth.