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Big Moves

Nvidia board continues Huang probe as Congress demands December testimony ↗

After Jensen Huang resigned on Nov. 12, NBC News reported that Nvidia’s independent directors plan to keep investigating him. House committees asked him to appear for a closed-door interview on Dec. 1, and the Senate Banking Committee asked him to testify on Dec. 3, with subpoena threats if he does not. The board told CNBC it has not yet selected a search firm or formally engaged candidates.

Holy Shit Tech

TMEM184: Scientists Find the Long-Sought Lysosome Calcium Uptake Transporter ↗

A Zhejiang University team led by Haoxing Xu reports in Science that TMEM184B and TMEM184C are the transporters that move calcium into lysosomes, answering a question open since 1991. The proteins refill lysosomal calcium without energy or acid, and a TMEM184B mutation linked to a neurodevelopmental disorder breaks the transport.

Holy Shit Tech

TLR4 Immune Receptor Has a Hidden Enzyme That Makes Its Own Molecular Glue ↗

A Shanghai Jiao Tong University-led team reports in Science that the TLR4 immune receptor's TIR domain, long described as an inert scaffold, is a single-use enzyme. It cuts NAD+ into ADP-ribose and keeps the product as molecular glue that locks the inflammation signaling complex together. Mice without this enzyme activity all survived an endotoxin shock test.

Big Moves

OpenAI Disbands Its Robotics Team, Betting GPT-6 Astra Can Run Robots Directly ↗

OpenAI has disbanded its stand-alone robotics team, Fortune reported and OpenAI confirmed. Researchers move under Chief Research Officer Mark Chen, and applied robotics and hardware staff move to Greg Brockman's Applied organization. OpenAI says general models like GPT-6 Astra can now handle some robot tasks directly, so it no longer needs a separate robot brain.